T-box transcription factors are crucial developmental regulators, and they have not previously been associated with SUMOylation. In Caenorhabditis elegans, the Tbx2 subfamily member TBX-2 (T-box protein 2) is required for anterior pharyngeal muscle development. TBX-2 interacts with SUMOylation pathway enzymes, and loss of these enzymes phenocopies tbx-2 mutants. We hypothesize that TBX-2 functions as a SUMOylation-dependent transcriptional repressor. TBX-2 contains two consensus SUMOylation sites conserved in many T-box transcriptional repressors, and we suggest that the function of these T-box factors may similarly involve SUMOylation.
Conference Article| November 23 2007
SUMOylation-dependent function of a T-box transcriptional repressor in Caenorhabditis elegans
P.G. Okkema 1
1Department of Biological Sciences and Laboratory for Molecular Biology, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, IL 60607, U.S.A.
1To whom correspondence should be addressed (email email@example.com).
Search for other works by this author on:
- Views Icon Views
- Share Icon Share
T.L. Crum, P.G. Okkema; SUMOylation-dependent function of a T-box transcriptional repressor in Caenorhabditis elegans. Biochem Soc Trans 1 December 2007; 35 (6): 1424–1426. doi: https://doi.org/10.1042/BST0351424
Download citation file: