Viral recognition is mediated by different classes of PRRs (pattern-recognition receptors) among which the TLRs (Toll-like receptors) and the RLHs [RIG (retinoic-acid-inducible)-like helicases] play major roles. The detection of PAMPs (pathogen-associated molecular patterns) by these PRRs leads to the initiation of signalling pathways that ultimately result in the activation of transcription factors such as NF-κB (nuclear factor κB) and IRF-3 [IFN (interferon) regulatory factor-3] and IRF-7 and the induction of pro-inflammatory cytokines and type I IFNs. Viruses have evolved a fine-tuned mechanism to evade detection by the immune system or to interfere with the resulting signalling pathways. Here, we discuss viral evasion proteins that specifically interfere with TLR and/or RLH signalling.
Conference Article| November 23 2007
An arms race: innate antiviral responses and counteracting viral strategies
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M. Schröder, A.G. Bowie; An arms race: innate antiviral responses and counteracting viral strategies. Biochem Soc Trans 1 December 2007; 35 (6): 1512–1514. doi: https://doi.org/10.1042/BST0351512
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