Growth inhibition of Saccharomyces cerevisiae by the plasmid-encoded trimeric (αβγ) zymocin toxin from dairy yeast, Kluyveromyces lactis, depends on a multistep response pathway in budding yeast. Following early processes that mediate cell-surface contact by the chitinase α-subunit of zymocin, later steps enable import of the γ-toxin tRNase subunit and cleavage of target tRNAs that carry modified U34 (wobble uridine) bases. With the emergence of zymocin-like toxins, continued zymocin research is expected to yield new insights into the evolution of yeast pathosystems and their lethal modes of action.
Conference Article| November 23 2007
Zymocin, a composite chitinase and tRNase killer toxin from yeast
R. Schaffrath 1
1Biologicum, Institut für Biologie, Bereich Genetik, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 10, D-06120 Halle/Saale, Germany
1To whom correspondence should be addressed (email email@example.com).
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D. Jablonowski, R. Schaffrath; Zymocin, a composite chitinase and tRNase killer toxin from yeast. Biochem Soc Trans 1 December 2007; 35 (6): 1533–1537. doi: https://doi.org/10.1042/BST0351533
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