The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeacons™, split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems. Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield.
Molecular probes: insights into design and analysis from computational and physical chemistry
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Felicity L. Mitchell, Gabriel E. Marks, Elena V. Bichenkova, Kenneth T. Douglas, Richard A. Bryce; Molecular probes: insights into design and analysis from computational and physical chemistry. Biochem Soc Trans 1 February 2008; 36 (1): 46–50. doi: https://doi.org/10.1042/BST0360046
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