The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nucleotide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. In addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.
Conference Article| January 22 2008
AAA+ proteins: diversity in function, similarity in structure
Walid A. Houry
Walid A. Houry 1
1King's College Circle, Medical Sciences Building, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Jamie Snider, Walid A. Houry; AAA+ proteins: diversity in function, similarity in structure. Biochem Soc Trans 1 February 2008; 36 (1): 72–77. doi: https://doi.org/10.1042/BST0360072
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