Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth factor receptors). Even partial tissue-specific attenuation of EGFR signalling in the islets leads to markedly reduced β-cell proliferation and development of diabetes during the first weeks after birth. Out of the many EGFR ligands, betacellulin has been specifically associated with positive effects on β-cell growth, through both increased proliferation and neogenesis. EGFR action is also necessary for the β-cell mitogenic activity of the gut hormone GLP-1 (glucagon-like peptide 1). Finally, in vitro models demonstrate a central role for EGFR in transdifferentiation of pancreatic acinar and ductal cells into endocrine islet cells. EGFR thus plays an essential role in β-cell mass regulation, but its mechanisms of action remain poorly understood.
Conference Article| May 21 2008
EGF receptor in pancreatic β-cell mass regulation
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Päivi Miettinen, Päivi Ormio, Elina Hakonen, Meenal Banerjee, Timo Otonkoski; EGF receptor in pancreatic β-cell mass regulation. Biochem Soc Trans 1 June 2008; 36 (3): 280–285. doi: https://doi.org/10.1042/BST0360280
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