Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that β-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcription factors such as NF-κB (nuclear factor κB) and STAT-1 (signal transducer and activator of transcription 1). Understanding the regulation of these gene networks, and how they modulate β-cell death and the ‘dialogue’ between β-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a ‘trial-and-error’ approach to one that is really mechanistically driven.
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June 2008
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Conference Article|
May 21 2008
Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes
Decio L. Eizirik;
Decio L. Eizirik
1
1Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium
1To whom correspondence should be addressed (email deizirik@ulb.ac.be).
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Fabrice Moore;
Fabrice Moore
1Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium
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Daisy Flamez;
Daisy Flamez
1Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium
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Fernanda Ortis
Fernanda Ortis
1Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium
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Biochem Soc Trans (2008) 36 (3): 321–327.
Article history
Received:
November 30 2007
Citation
Decio L. Eizirik, Fabrice Moore, Daisy Flamez, Fernanda Ortis; Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes. Biochem Soc Trans 1 June 2008; 36 (3): 321–327. doi: https://doi.org/10.1042/BST0360321
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