Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.
Regulation of gene expression by the RNA-binding protein Sam68 in cancer
Prabhakar Rajan, Luke Gaughan, Caroline Dalgliesh, Amira El-Sherif, Craig N. Robson, Hing Y. Leung, David J. Elliott; Regulation of gene expression by the RNA-binding protein Sam68 in cancer. Biochem Soc Trans 1 June 2008; 36 (3): 505–507. doi: https://doi.org/10.1042/BST0360505
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