We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA
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Andrew P. Harrison, Joanna Rowsell, Renata da Silva Camargo, William B. Langdon, Maria Stalteri, Graham J.G. Upton, Jose M. Arteaga-Salas; The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA. Biochem Soc Trans 1 June 2008; 36 (3): 511–513. doi: https://doi.org/10.1042/BST0360511
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