Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the current understanding in view of recent developments.
Conference Article| May 21 2008
Nonsense-mediated mRNA decay
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Jikai Wen, Saverio Brogna; Nonsense-mediated mRNA decay. Biochem Soc Trans 1 June 2008; 36 (3): 514–516. doi: https://doi.org/10.1042/BST0360514
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