The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.
Conference Article| July 22 2008
The role of the Wilms' tumour-suppressor protein WT1 in apoptosis
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Jörg Hartkamp, Stefan G.E. Roberts; The role of the Wilms' tumour-suppressor protein WT1 in apoptosis. Biochem Soc Trans 1 August 2008; 36 (4): 629–631. doi: https://doi.org/10.1042/BST0360629
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