Many quinone-reactive enzyme complexes that are part of membrane-integral eukaryotic or prokaryotic respiratory electron transport chains contain one or more haem b molecules embedded in the membrane. In recent years, various novel proteins have emerged that are devoid of haem b but are thought to fulfil a similar function in bacterial anaerobic respiratory systems. These proteins are encoded by genes organized in various genomic arrangements and are thought to form widespread membrane-bound quinone-reactive electron transport modules that exchange electrons with redox partner proteins located at the outer side of the cytoplasmic membrane. Prototypic representatives are the multihaem c-type cytochromes NapC, NrfH and TorC (NapC/NrfH family), the putative iron–sulfur protein NapH and representatives of the NrfD/PsrC family. Members of these protein families vary in the number of their predicted transmembrane segments and, consequently, diverse quinone-binding sites are expected. Only a few of these enzymes have been isolated and characterized biochemically and high-resolution structures are limited. This mini-review briefly summarizes predicted and experimentally demonstrated properties of the proteins in question and discusses their role in electron transport and bioenergetics of anaerobic respiration.
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Conference Article|
September 19 2008
Quinone-reactive proteins devoid of haem b form widespread membrane-bound electron transport modules in bacterial respiration
Jörg Simon;
Jörg Simon
1
1Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany
1To whom correspondence should be addressed (email [email protected]).
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Melanie Kern
Melanie Kern
1Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany
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Publisher: Portland Press Ltd
Received:
April 08 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 1011–1016.
Article history
Received:
April 08 2008
Citation
Jörg Simon, Melanie Kern; Quinone-reactive proteins devoid of haem b form widespread membrane-bound electron transport modules in bacterial respiration. Biochem Soc Trans 1 October 2008; 36 (5): 1011–1016. doi: https://doi.org/10.1042/BST0361011
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