Saccharomyces cerevisiae (baker's yeast) is an excellent model for understanding fundamental biological mechanisms that are conserved in Nature and that have an impact on human disease. The metal iron is a redox-active cofactor that plays critical biochemical roles in a broad range of functions, including oxygen transport, mitochondrial oxidative phosphorylation, chromatin remodelling, intermediary metabolism and signalling. Although iron deficiency is the most common nutritional disorder on the planet, little is known about the metabolic adjustments that cells undergo in response to iron deficit and the regulatory mechanisms that allow these adaptive responses. In the present article, we summarize recent work on genome-wide metabolic reprogramming in response to iron deficiency, mediated by specific mRNA degradation mechanisms that allow S. cerevisiae cells to adapt to iron deficiency.
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Conference Article|
September 19 2008
Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins
Sandra V. Vergara;
Sandra V. Vergara
1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, U.S.A.
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Dennis J. Thiele
Dennis J. Thiele
1
1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, U.S.A.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
March 17 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 1088–1090.
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Received:
March 17 2008
Citation
Sandra V. Vergara, Dennis J. Thiele; Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins. Biochem Soc Trans 1 October 2008; 36 (5): 1088–1090. doi: https://doi.org/10.1042/BST0361088
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