Proteolysis has traditionally been considered as a radical way to terminate the function of a protein. However, protein destruction also is the starting point for many processes as they can only occur when the way has been cleared for the action of other proteins. Protein destruction can occur virtually in all compartments and organelles of the cell, associated with cell membranes or large protein complexes, it determines subcellular partitioning, association with positive or negative regulators which conditions the action of many critical cellular factors. The third intracellular proteolysis meeting held by the University La Laguna, Canary Islands, Spain, included speakers working with some of the most important proteolytic systems present in higher eukaryotes, such as the UPS (ubiquitin–proteasome system) and autophagy. Owing to the fact that these pathways directly or indirectly regulate many cell functions, this meeting brought together an audience with a wide range of research interests, including genetic, cell biological, biochemical and structural aspects of protein degradation. Some of these topics inspired interesting discussions and a significant number of these are developed in the issues reviewed herein.
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October 2008
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Conference Article|
September 19 2008
Much to know about proteolysis: intricate proteolytic machineries compromise essential cellular functions
Gemma Marfany;
Gemma Marfany
*Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain
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Rosa Farràs;
Rosa Farràs
†Molecular Haematology Unit, Centro de Investigación Príncipe Felipe, c/EP Autopista del Saler, 16 Camino de las Moreras, 46012 Valencia, Spain
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Eduardo Salido;
Eduardo Salido
‡Molecular Pathology, CIBERer, Hospital Universitario de Canarias, University La Laguna, 38320 Tenerife, Canary Islands, Spain
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Dimitris P. Xirodimas;
Dimitris P. Xirodimas
§Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.
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Manuel S. Rodríguez
Manuel S. Rodríguez
1
∥Ubiquitin-Like Molecules and Cancer Laboratory, Proteomics Unit, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Building 801A, 48160 Derio, Spain
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 26 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 781–785.
Article history
Received:
June 26 2008
Citation
Gemma Marfany, Rosa Farràs, Eduardo Salido, Dimitris P. Xirodimas, Manuel S. Rodríguez; Much to know about proteolysis: intricate proteolytic machineries compromise essential cellular functions. Biochem Soc Trans 1 October 2008; 36 (5): 781–785. doi: https://doi.org/10.1042/BST0360781
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