Ub (ubiquitin) and Ubls (Ub-like molecules) are peptide modifiers that change the fate and function of their substrates. A plethora of enzyme activities and protein cofactors are required for either the conjugation (mainly E3 ligases) or deconjugation of Ub and Ubls. Most of the data have been gathered on describing individual enzymes and their partners, but an increasing number of reports point to the formation of multisubunit complexes regulated by cross-talk between Ub and Ubl systems and which contain opposing conjugation/deconjugation activities. This minireview focuses on these latest reports and proposes that these complexes, which are able to recruit transient partners, shift cofactors and integrate different signalling stimuli, are a common strategy to regulate highly dynamic processes, in a switch-on/switch-off type of mechanism, thus responding promptly to cellular requirements.
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October 2008
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Conference Article|
September 19 2008
To ubiquitinate or to deubiquitinate: it all depends on the partners
Gemma Marfany;
Gemma Marfany
1
*Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain
†IBUB (Institut de Biomedicina de la Universitat de Barcelona), Universitat de Barcelona, 08028 Barcelona, Spain
1To whom correspondence should be addressed (email [email protected]).
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Amanda Denuc
Amanda Denuc
*Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain
†IBUB (Institut de Biomedicina de la Universitat de Barcelona), Universitat de Barcelona, 08028 Barcelona, Spain
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Publisher: Portland Press Ltd
Received:
April 21 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 833–838.
Article history
Received:
April 21 2008
Citation
Gemma Marfany, Amanda Denuc; To ubiquitinate or to deubiquitinate: it all depends on the partners. Biochem Soc Trans 1 October 2008; 36 (5): 833–838. doi: https://doi.org/10.1042/BST0360833
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