JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence inducer and a tumour suppressor. As for the molecular mechanisms involved, they largely involve both positive actions on genes such as the p16INK4α cyclin-dependent kinase inhibitor and negative effects on genes such as cyclin D1 during the G1-phase of the cell cycle. However, JunB is also endowed with a cell-division-promoting activity, in particular via stimulation of cyclin A2 gene expression during S-phase. Strikingly, its role in G2 and M has received little attention so far despite its possible role in the preparation of mitosis. This review addresses the known and possible mechanisms whereby JunB is implicated in the control of the different phases of the cell cycle.
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October 2008
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Conference Article|
September 19 2008
Regulation and function of JunB in cell proliferation
Marc Piechaczyk;
Marc Piechaczyk
1
*IGMM (Institut de Génétique Moléculaire de Montpellier), CNRS, 1919 route de Mende, 34293 Montpellier Cedex 05, France
1Correspondence may be addressed to either of the authors (email [email protected] or [email protected]).
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Rosa Farràs
Rosa Farràs
1
†Centro de Investigación Príncipe Felipe, c/EP Autopista del Saler, 16 Camino de las Moreras, 46013 Valencia, Spain
1Correspondence may be addressed to either of the authors (email [email protected] or [email protected]).
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Publisher: Portland Press Ltd
Received:
March 14 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 864–867.
Article history
Received:
March 14 2008
Citation
Marc Piechaczyk, Rosa Farràs; Regulation and function of JunB in cell proliferation. Biochem Soc Trans 1 October 2008; 36 (5): 864–867. doi: https://doi.org/10.1042/BST0360864
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