Peptide generation by the UPS (ubiquitin–proteasome system) is rate-limiting in MHC class I-restricted antigen presentation in response to virus-induced IFNs (interferons). In this process, the role of IFN-induced rapid remodelling of the UPS is less defined. IFN-mediated de novo formation of different proteasome compositions as i20S (immunoproteasomes) or m20S (mixed-type proteasomes) essentially supports the rapid adjustment of the mammalian immune system to pathogens. This adjustment is of particular importance for the immune response to rapidly replicating viruses. In agreement, i20S formation has been shown to be an accelerated and transient response. Moreover, i20S and/or PA28 (proteasome activator 28) are essentially required for the generation of certain viral epitopes. In the present paper, we discuss how IFNs consecutively regulate the UPS at different levels, thereby improving the immune responsiveness of target cells.
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Conference Article|
September 19 2008
Remodelling of the ubiquitin–proteasome system in response to interferons
Ulrike Seifert;
Ulrike Seifert
1Institut für Biochemie, Charité – Universitätsmedizin Berlin, CCM (Campus Charité Mitte), Monbijoustrasse 2, 10117 Berlin, Germany
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Elke Krüger
Elke Krüger
1
1Institut für Biochemie, Charité – Universitätsmedizin Berlin, CCM (Campus Charité Mitte), Monbijoustrasse 2, 10117 Berlin, Germany
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
March 03 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 879–884.
Article history
Received:
March 03 2008
Citation
Ulrike Seifert, Elke Krüger; Remodelling of the ubiquitin–proteasome system in response to interferons. Biochem Soc Trans 1 October 2008; 36 (5): 879–884. doi: https://doi.org/10.1042/BST0360879
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