Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence of Type 2 diabetes in humans. However, when incubated in vitro, β-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms. In particular, it is clear that, whereas saturated fatty acids [e.g. palmitate (C16:0)] exert detrimental effects on β-cells, the equivalent mono-unsaturated species [e.g. palmitoleate (C16:1)] are well tolerated. Indeed, mono-unsaturated species are potently cytoprotective. The present review explores the differential effects of these various fatty acids on β-cell viability and considers the possible mechanisms involved in cytoprotection by mono-unsaturates.
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October 2008
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Conference Article|
September 19 2008
The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells
Noel G. Morgan;
Noel G. Morgan
1
1Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Shalinee Dhayal;
Shalinee Dhayal
1Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, U.K.
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Eleftheria Diakogiannaki;
Eleftheria Diakogiannaki
1Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, U.K.
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Hannah J. Welters
Hannah J. Welters
1Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, U.K.
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Publisher: Portland Press Ltd
Received:
April 21 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (5): 905–908.
Article history
Received:
April 21 2008
Citation
Noel G. Morgan, Shalinee Dhayal, Eleftheria Diakogiannaki, Hannah J. Welters; The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells. Biochem Soc Trans 1 October 2008; 36 (5): 905–908. doi: https://doi.org/10.1042/BST0360905
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