Zinc, essential for normal cell growth, is tightly controlled in cells by two families of zinc transporters. The aberrant expression of zinc transporters from the LIV-1 family of ZIP (Zrt/Irt-like protein) transporters is increasingly being implicated in a variety of disease states. In the present paper, I describe a mechanism for the role of ZIP7 in the progression of breast cancer, identifying it as a new target in breast cancer. Furthermore, I document a link between another zinc transporter, LIV-1, and breast cancer metastasis, identifying it as a potential new prognostic indicator of breast cancer spread.
Conference Article| November 19 2008
A distinct role in breast cancer for two LIV-1 family zinc transporters
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Kathryn M. Taylor; A distinct role in breast cancer for two LIV-1 family zinc transporters. Biochem Soc Trans 1 December 2008; 36 (6): 1247–1251. doi: https://doi.org/10.1042/BST0361247
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