Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. Chelation therapy could provide a valuable therapeutic approach to such disease states, since metals, particularly iron, are realistic pharmacological targets for the rational design of new therapeutic agents.
Iron chelation as a potential therapy for neurodegenerative disease
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Robert C. Hider, Yongmin Ma, Francisco Molina-Holgado, Alessandra Gaeta, Sourav Roy; Iron chelation as a potential therapy for neurodegenerative disease. Biochem Soc Trans 1 December 2008; 36 (6): 1304–1308. doi: https://doi.org/10.1042/BST0361304
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