ESCRT-III (endosomal sorting complex required for transport III) is required for the formation and abscission of intraluminal endosomal vesicles, which gives rise to multivesicular bodies, budding of some enveloped viruses and cytokinesis. ESCRT-III is composed of 11 members in humans, which, except for one, correspond to the six ESCRT-III-like proteins in yeast. At least CHMP (charged multivesicular body protein) 2A and CHMP3 assemble into helical tubular structures that provide a platform for membrane interaction and VPS (vacuolar protein sorting) 4-catalysed effects leading to disassembly of ESCRT-III CHMP2A–CHMP3 polymers in vitro. Progress towards the understanding of the structures and function of ESCRT-III, its activation, its regulation by accessory factors and its role in abscission of membrane enveloped structures in concert with VPS4 are discussed.
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February 2009
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Conference Article|
January 20 2009
Structure and function of ESCRT-III
Suman Lata;
Suman Lata
*Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
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Guy Schoehn;
Guy Schoehn
*Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
†Institut de Biologie Structurale Jean-Pierre UMR 5075 CEA-CNRS-UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
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Julianna Solomons;
Julianna Solomons
*Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
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Ricardo Pires;
Ricardo Pires
*Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
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Heinrich G. Göttlinger;
Heinrich G. Göttlinger
‡Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.
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Winfried Weissenhorn
Winfried Weissenhorn
1
*Unit for Virus Host Cell Interaction, UMR 5233 UJF-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
August 01 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 156–160.
Article history
Received:
August 01 2008
Citation
Suman Lata, Guy Schoehn, Julianna Solomons, Ricardo Pires, Heinrich G. Göttlinger, Winfried Weissenhorn; Structure and function of ESCRT-III. Biochem Soc Trans 1 February 2009; 37 (1): 156–160. doi: https://doi.org/10.1042/BST0370156
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