The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases.
Conference Article| January 20 2009
ESCRTs and human disease
Scott D. Emr
Scott D. Emr 1
1Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, 441 Weill Hall, Cornell University, Ithaca, NY 14853, U.S.A.
1To whom correspondence should be addressed (email email@example.com).
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Suraj Saksena, Scott D. Emr; ESCRTs and human disease. Biochem Soc Trans 1 February 2009; 37 (1): 167–172. doi: https://doi.org/10.1042/BST0370167
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