Mechanisms involved in DNA repair and genome maintenance are essential for all organisms on Earth and have been studied intensively in bacteria and eukaryotes. Their analysis in extremely thermophilic archaea offers the opportunity to discover strategies for maintaining genome integrity of the relatively little explored third domain of life, thereby shedding light on the diversity and evolution of these central and important systems. These studies might also reveal special adaptations that are essential for life at high temperature. A number of investigations of the hyperthermophilic and acidophilic crenarchaeote Sulfolobus solfataricus have been performed in recent years. Mostly, the reactions to DNA damage caused by UV light have been analysed. Whole-genome transcriptomics have demonstrated that a UV-specific response in S. solfataricus does not involve the transcriptional induction of DNA-repair genes and it is therefore different from the well-known SOS response in bacteria. Nevertheless, the UV response in S. solfataricus is impressively complex and involves many different levels of action, some of which have been elucidated and shed light on novel strategies for DNA repair, while others involve proteins of unknown function whose actions in the cell remain to be elucidated. The present review summarizes and discusses recent investigations on the UV response of S. solfataricus on both the molecular biological and the cellular levels.
Skip Nav Destination
Article navigation
February 2009
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
January 20 2009
Reactions to UV damage in the model archaeon Sulfolobus solfataricus Available to Purchase
Sabrina Fröls;
Sabrina Fröls
*Department of Genetics in Ecology, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
†Center for Geobiology, University of Bergen, Allegaten 41, 5007 Bergen, Norway
Search for other works by this author on:
Malcolm F. White;
Malcolm F. White
‡Center for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9ST, U.K.
Search for other works by this author on:
Christa Schleper
Christa Schleper
1
*Department of Genetics in Ecology, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
†Center for Geobiology, University of Bergen, Allegaten 41, 5007 Bergen, Norway
1To whom correspondence should be addressed (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 28 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 36–41.
Article history
Received:
October 28 2008
Citation
Sabrina Fröls, Malcolm F. White, Christa Schleper; Reactions to UV damage in the model archaeon Sulfolobus solfataricus. Biochem Soc Trans 1 February 2009; 37 (1): 36–41. doi: https://doi.org/10.1042/BST0370036
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Get Email Alerts
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |