In order for any organism to replicate its DNA, a helicase must unwind the duplex DNA in front of the replication fork. In archaea, the replicative helicase is the MCM (minichromosome maintenance) helicase. Although much is known about the biochemical properties of the MCM helicase, the mechanism of assembly at the origin of replication is unknown. In the present paper, several possible mechanisms for the loading process are described.
Conference Article| January 20 2009
How is the archaeal MCM helicase assembled at the origin? Possible mechanisms
Lori M. Kelman;
Zvi Kelman 1
*University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Nozomi Sakakibara, Lori M. Kelman, Zvi Kelman; How is the archaeal MCM helicase assembled at the origin? Possible mechanisms. Biochem Soc Trans 1 February 2009; 37 (1): 7–11. doi: https://doi.org/10.1042/BST0370007
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