Quinone oxidoreductases are a class of membrane enzymes that catalyse the oxidation or reduction of membrane-bound quinols/quinones. The conversion of quinone/quinol by these enzymes is difficult to study because of the hydrophobic nature of the enzymes and their substrates. We describe some biochemical properties of quinones and quinone oxidoreductases and then look in more detail at two model membranes that can be used to study quinone oxidoreductases in a native-like membrane environment with their native lipophilic quinone substrates. The results obtained with these model membranes are compared with classical enzyme assays that use water-soluble quinone analogues.
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Conference Article| July 22 2009
Electrodes modified with lipid membranes to study quinone oxidoreductases
Sophie A. Weiss;
Lars J.C. Jeuken
Lars J.C. Jeuken 1
*School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, U.K.
†Centre for Self Organising Molecular Systems, University of Leeds, Leeds LS2 9JT, U.K.
‡Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Sophie A. Weiss, Lars J.C. Jeuken; Electrodes modified with lipid membranes to study quinone oxidoreductases. Biochem Soc Trans 1 August 2009; 37 (4): 707–712. doi: https://doi.org/10.1042/BST0370707
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