The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure–function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein–protein complexes.
The evolution of protein functions and networks: a family-centric approach
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Benoît H. Dessailly, Adam J. Reid, Corin Yeats, Jonathan G. Lees, Alison Cuff, Christine A. Orengo; The evolution of protein functions and networks: a family-centric approach. Biochem Soc Trans 1 August 2009; 37 (4): 745–750. doi: https://doi.org/10.1042/BST0370745
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