The inability of the human heart to effectively repair itself after acute ischaemic injury has driven the search for efficacious means of promoting cardiac regenerative growth. Central to this has been the emergence of cell-based strategies to stimulate and augment both myocardial regeneration and neovascularization. Autologous cell transplantation of a variety of adult progenitor cells has been taken forward in clinical trials and, in parallel, investigators have begun to focus on the activation of resident cardiac cell populations as a means to stimulate endogenous repair. The latter approach depends on characterizing native progenitors with self-renewal, clonality, multipotency and arguably an analogous embryological counterpart. Recently, we have focused on adult EPDCs (epicardium-derived progenitor cells), which, when induced by the actin monomer-binding protein Tβ4 (thymosin β4), are able to revert to their embryonic phenotype and give rise to endothelial cells and vascular smooth muscle cells ex vivo. Studies are ongoing to determine whether activated adult EPDCs can contribute to bona fide neovascularization in the injured adult mammalian heart proper, as a therapeutic means to support surviving cardiac muscle cells and sustain regenerating myocardium.
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December 2009
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Conference Article|
November 19 2009
Thymosin β4 induces epicardium-derived neovascularization in the adult heart
Paul R. Riley;
Paul R. Riley
1
1UCL-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Nicola Smart
Nicola Smart
1UCL-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K.
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Publisher: Portland Press Ltd
Received:
May 01 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (6): 1218–1220.
Article history
Received:
May 01 2009
Citation
Paul R. Riley, Nicola Smart; Thymosin β4 induces epicardium-derived neovascularization in the adult heart. Biochem Soc Trans 1 December 2009; 37 (6): 1218–1220. doi: https://doi.org/10.1042/BST0371218
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