ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.
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December 2009
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Conference Article|
November 19 2009
ERK5 and the regulation of endothelial cell function
Owain Llŷr Roberts;
Owain Llŷr Roberts
*NWCRF Institute, School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor LL57 2UW, U.K.
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Katherine Holmes;
Katherine Holmes
†Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3GE, U.K.
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Jürgen Müller;
Jürgen Müller
‡Warwick Medical School, Clinical Sciences Research Institute, University of Warwick, Coventry CV4 7AL, U.K.
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Darren A.E. Cross;
Darren A.E. Cross
§AstraZeneca, Alderley Park, Cheshire SK10 4TG, U.K.
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Michael J. Cross
Michael J. Cross
1
†Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3GE, U.K.
1To whom correspondence should be addressed (email m.j.cross@liv.ac.uk).
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Biochem Soc Trans (2009) 37 (6): 1254–1259.
Article history
Received:
August 05 2009
Citation
Owain Llŷr Roberts, Katherine Holmes, Jürgen Müller, Darren A.E. Cross, Michael J. Cross; ERK5 and the regulation of endothelial cell function. Biochem Soc Trans 1 December 2009; 37 (6): 1254–1259. doi: https://doi.org/10.1042/BST0371254
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