Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.
Conference Article| November 19 2009
Gene expression networks: competing mRNA decay pathways in mammalian cells
Lynne E. Maquat;
Lynne E. Maquat 1
1Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, U.S.A.
1To whom correspondence should be addressed (email email@example.com).
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Lynne E. Maquat, Chenguang Gong; Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans 1 December 2009; 37 (6): 1287–1292. doi: https://doi.org/10.1042/BST0371287
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