RDL receptors are invertebrate members of the Cys-loop family of ligand-gated ion channels. They are GABA (γ-aminobutyric acid)-activated chloride-selective receptors that are closely related to their vertebrate orthologues, the GABAA receptors, as well as other Cys-loop receptors such as the ionotropic glycine, nicotinic acetylcholine and 5-HT3 receptors. RDL receptors are widely expressed throughout the insect CNS (central nervous system) and are important in inhibitory neurotransmission. They are therefore a major insecticidal target site.

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