Stroke is the leading cause of adult disability. Recent studies show that the brain can engage in a limited process of neural repair after stroke: re-mapping of sensory and motor function and sprouting of new connections in peri-infarct cortex surrounding the stroke. Changes in cortical sensory and motor maps and alterations in axonal structure are dependent on patterned neuronal activity. The central cellular process in these events is alteration in neuronal response to incoming inputs – manipulations that increase neuronal firing to a given input are likely to induce changes in neuronal structure and alterations in cortical maps. Because post-stroke neural repair and recovery also involves neuronal sprouting and re-mapping of cortical sensory and motor representations, it has been assumed that changes in neuronal excitability underlie neural repair.
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December 2009
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Conference Article|
November 19 2009
Cortical excitability and post-stroke recovery Available to Purchase
Andrew N. Clarkson;
Andrew N. Clarkson
1
1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U.S.A.
1Correspondence may be addressed to either of the authors (email [email protected] or [email protected]).
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S. Tomas Carmichael
S. Tomas Carmichael
1
1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U.S.A.
1Correspondence may be addressed to either of the authors (email [email protected] or [email protected]).
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Publisher: Portland Press Ltd
Received:
July 16 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (6): 1412–1414.
Article history
Received:
July 16 2009
Citation
Andrew N. Clarkson, S. Tomas Carmichael; Cortical excitability and post-stroke recovery. Biochem Soc Trans 1 December 2009; 37 (6): 1412–1414. doi: https://doi.org/10.1042/BST0371412
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