Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. In the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis.
Conference Article| November 19 2009
Potential role for ligand-gated ion channels after seizure-induced neurogenesis
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Ann Swijsen, Govert Hoogland, Jean-Michel Rigo; Potential role for ligand-gated ion channels after seizure-induced neurogenesis. Biochem Soc Trans 1 December 2009; 37 (6): 1419–1422. doi: https://doi.org/10.1042/BST0371419
Download citation file: