The p53 family of transcription factors is made up of p53, p63 and p73, which share significant structural homology. In particular, transcriptional complexity and the expression of multiple protein isoforms are an emergent trait of all family members. p63 is the evolutionarily eldest member of the p53 family and the various isoforms have critical roles in the development of stratifying epithelia. Recent results have uncovered additional splice variants, adding to the complexity of the transcriptional architecture of p63. These observations and the emerging extensive interplay between p63 and p53 in development, proliferation and differentiation underline the importance of considering all isoforms and family members in studies of the function of p53 family members.
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Conference Article| January 19 2010
The role of p63 in epidermal morphogenesis and neoplasia
Simon S. McDade;
Dennis J. McCance
Dennis J. McCance 1
1Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, U.K.
1To whom correspondence should be addressed (email email@example.com).
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Publisher: Portland Press Ltd
Received: October 02 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
Simon S. McDade, Dennis J. McCance; The role of p63 in epidermal morphogenesis and neoplasia. Biochem Soc Trans 1 February 2010; 38 (1): 223–228. doi: https://doi.org/10.1042/BST0380223
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