A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.
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Conference Article| March 22 2010
S-acylation by the DHHC protein family
Jennifer Greaves 1
1Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, U.K.
1To whom correspondence should be addressed (email J.Greaves@ed.ac.uk).
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Jennifer Greaves, Luke H. Chamberlain; S-acylation by the DHHC protein family. Biochem Soc Trans 1 April 2010; 38 (2): 522–524. doi: https://doi.org/10.1042/BST0380522
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