The signalling roles of Ca2+ic (intracellular Ca2+) stores are well established in non-neuronal and neuronal cells. In neurons, although Ca2+ic stores have been assigned a pivotal role in postsynaptic responses to Gq-coupled receptors, or secondarily to extracellular Ca2+ influx, the functions of dynamic Ca2+ic stores in presynaptic terminals remain to be fully elucidated. In the present paper, we review some of the recent evidence supporting an involvement of Ca2+ic in presynaptic function, and discuss loci at which this source of Ca2+ may impinge. Nerve terminal preparations provide good models for functionally examining putative Ca2+ic stores under physiological and pathophysiological stimulation paradigms, using Ca2+-dependent activation of resident protein kinases as sensors for fine changes in intracellular Ca2+ levels. We conclude that intraterminal Ca2+ic stores may, directly or indirectly, enhance neurotransmitter release following nerve terminal depolarization and/or G-protein-coupled receptor activation. During conditions that prevail following neuronal ischaemia, increased glutamate release instigated by Ca2+ic store activation may thereby contribute to excitotoxicity and eventual synaptopathy.
Presynaptic roles of intracellular Ca2+ stores in signalling and exocytosis
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Sohaib Nizami, Vivian W.Y. Lee, Jennifer Davies, Philip Long, Jasmina N. Jovanovic, Talvinder S. Sihra; Presynaptic roles of intracellular Ca2+ stores in signalling and exocytosis. Biochem Soc Trans 1 April 2010; 38 (2): 529–535. doi: https://doi.org/10.1042/BST0380529
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