The modelling of OXPHOS (oxidative phosphorylation) in order to integrate all kinetic and thermodynamic aspects of chemiosmotic theory has a long history. We briefly review this history and show how new ways of modelling are required to integrate a local model of the individual respiratory complexes into a global model of OXPHOS and, beyond that, into a reliable overall model of central metabolism.
Virtual mitochondrion: towards an integrated model of oxidative phosphorylation complexes and beyond
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Jean-Pierre Mazat, Jonathan Fromentin, Margit Heiske, Christine Nazaret, Stéphane Ransac; Virtual mitochondrion: towards an integrated model of oxidative phosphorylation complexes and beyond. Biochem Soc Trans 1 October 2010; 38 (5): 1215–1219. doi: https://doi.org/10.1042/BST0381215
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