Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)–CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism).
Conference Article| September 24 2010
Systems-level feedback in cell-cycle control
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Béla Novák, P.K. Vinod, Paula Freire, Orsolya Kapuy; Systems-level feedback in cell-cycle control. Biochem Soc Trans 1 October 2010; 38 (5): 1242–1246. doi: https://doi.org/10.1042/BST0381242
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