HSs (heparan sulfates) are a complex family of cell-surface and matrix polysaccharides that have diverse biological functions, underpinned by structurally diverse patterns of backbone chain modification, especially by sulfate groups. These variant structures represent a molecular code, the ‘heparanome’, that confers the ability to interact selectively with a wide interactome of proteins, the ‘heparactome’, and thereby influence a network of cellular events. It is becoming increasingly apparent that understanding the structure–activity relationships of these enigmatic molecules requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other ‘-omics’ approaches to define the molecular code of the heparanome.
Conference Article| September 24 2010
Heparan sulfate glycomics: towards systems biology strategies
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Jeremy E. Turnbull; Heparan sulfate glycomics: towards systems biology strategies. Biochem Soc Trans 1 October 2010; 38 (5): 1356–1360. doi: https://doi.org/10.1042/BST0381356
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