The majority of mRNAs in eukaryotic cells are translated via a method that is dependent upon the recognition of, and binding to, the methylguanosine cap at the 5' end of the mRNA, by a set of protein factors termed eIFs (eukaryotic initiation factors). However, many of the eIFs involved in this process are modified and become less active under a number of pathophysiological stress conditions, including amino acid starvation, heat shock, hypoxia and apoptosis. During these conditions, the continued synthesis of proteins essential to recovery from stress or maintenance of a cellular programme is mediated via an alternative form of translation initiation termed IRES (internal ribosome entry site)-mediated translation. This relies on the mRNA containing a complex cis-acting structural element in its 5'-UTR (untranslated region) that is able to recruit the ribosome independently of the cap, and is often dependent upon additional factors termed ITAFs (IRES trans-acting factors). A limited number of ITAFs have been identified to date, particularly for cellular IRESs, and it is not yet fully understood how they exert their control and which cellular pathways are involved in their regulation.
Conference Article| November 24 2010
The role of IRES trans-acting factors in regulating translation initiation
Helen A. King;
Helen A. King
*School of Pharmacy, Centre for Biomolecular Science, University Park, University of Nottingham, Nottingham NG7 2RD, U.K.
†MRC Toxicology Unit, Hodgkin Building, Lancaster road, University of Leicester, Leicester LE1 9HN, U.K.
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Laura C. Cobbold;
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Helen A. King, Laura C. Cobbold, Anne E. Willis; The role of IRES trans-acting factors in regulating translation initiation. Biochem Soc Trans 1 December 2010; 38 (6): 1581–1586. doi: https://doi.org/10.1042/BST0381581
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