During the last 10 years it has become apparent that a significant subset of inherited muscular dystrophy is caused by errors in the glycosylation of α-dystroglycan. Many of these dystrophies are also associated with abnormalities of the central nervous system. Dystroglycan has to be fully glycosylated in order bind to its ligands. To date, six genes have been shown to be essential for functional dystroglycan glycosylation and most, if not all, of these genes act in the formation of O-mannosyl glycans. Genetic heterogeneity indicates that other genes are involved in this pathway. Identification of these additional genes would increase our understanding of this specific and essential glycosylation pathway.
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Conference Article| January 19 2011
Glycomarkers for muscular dystrophy
Jane E. Hewitt
Jane E. Hewitt 1
1Centre for Genetics and Genomics, School of Biology, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K.
1To whom correspondence should be addressed (email email@example.com).
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Publisher: Portland Press Ltd
Received: October 17 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
Jane E. Hewitt; Glycomarkers for muscular dystrophy. Biochem Soc Trans 1 February 2011; 39 (1): 336–339. doi: https://doi.org/10.1042/BST0390336
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