LBP [LPS (lipopolysaccharide)-binding protein] and BPI (bactericidal/permeability-increasing protein) are components of the immune system that have been principally studied in mammals for their involvement in defence against bacterial pathogens. These proteins share a basic architecture and residues involved in LPS binding. Putative orthologues, i.e. proteins encoded by similar genes that diverged from a common ancestor, have been found in a number of non-mammalian vertebrate species and several non-vertebrates. Similar to other aspects of immunity, such as the activity of Toll-like receptors and NOD (nucleotide-binding oligomerization domain) proteins, analysis of the conservation of LBPs and BPIs in the invertebrates promises to provide insight into features essential to the form and function of these molecules. This review considers state-of-the-art knowledge in the diversity of the LBP/BPI proteins across the eukaryotes and also considers their role in mutualistic symbioses. Recent studies of the LBPs and BPIs in an invertebrate model of beneficial associations, the Hawaiian bobtail squid Euprymna scolopes' alliance with the marine luminous bacterium Vibrio fischeri, are discussed as an example of the use of non-vertebrate models for the study of LBPs and BPIs.
Skip Nav Destination
Article navigation
August 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 20 2011
LBP/BPI proteins and their relatives: conservation over evolution and roles in mutualism Available to Purchase
Benjamin C. Krasity;
Benjamin C. Krasity
*Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin–Madison, 1550 Linden Drive, Madison, WI 53562, U.S.A.
Search for other works by this author on:
Joshua V. Troll;
Joshua V. Troll
*Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin–Madison, 1550 Linden Drive, Madison, WI 53562, U.S.A.
Search for other works by this author on:
Jerrold P. Weiss;
Jerrold P. Weiss
†Inflammation Program, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, U.S.A.
Search for other works by this author on:
Margaret J. McFall-Ngai
Margaret J. McFall-Ngai
1
*Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin–Madison, 1550 Linden Drive, Madison, WI 53562, U.S.A.
1To whom correspondence should be addressed (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 24 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (4): 1039–1044.
Article history
Received:
January 24 2011
Citation
Benjamin C. Krasity, Joshua V. Troll, Jerrold P. Weiss, Margaret J. McFall-Ngai; LBP/BPI proteins and their relatives: conservation over evolution and roles in mutualism. Biochem Soc Trans 1 August 2011; 39 (4): 1039–1044. doi: https://doi.org/10.1042/BST0391039
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Get Email Alerts
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |