In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.

Keywords:
Alzheimer's disease, amyloid β-peptide, complement system, disease modelling, genome-wide association study (GWAS), lipid metabolism
© The Authors Journal compilation © 2011 Biochemical Society
2011
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