It has become increasingly apparent in recent years that the subcellular localization of specific mRNAs is a prevalent method for spatially controlling gene expression. In most cases, targeting of mRNAs is mediated by transport along cytoskeletal filaments by molecular motors. However, the means by which specific messages are recognized and linked to the motors are poorly understood. Here, I will provide an overview of recent progress in elucidating the molecular mechanisms and principles of mRNA transport, including several studies highlighting the co-operation of different motors during the localization process. Important outstanding questions will also be highlighted.
Conference Article| September 21 2011
Messengers, motors and mysteries: sorting of eukaryotic mRNAs by cytoskeletal transport
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Simon L. Bullock; Messengers, motors and mysteries: sorting of eukaryotic mRNAs by cytoskeletal transport. Biochem Soc Trans 1 October 2011; 39 (5): 1161–1165. doi: https://doi.org/10.1042/BST0391161
Download citation file: