The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.
Conference Article| September 21 2011
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Victoria J. Allan; Cytoplasmic dynein. Biochem Soc Trans 1 October 2011; 39 (5): 1169–1178. doi: https://doi.org/10.1042/BST0391169
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