Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [URE3] prion state in Saccharomyces cerevisiae. Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state and loses its regulatory function. A number of molecular chaperones have been found to affect the prion properties of Ure2. The studies carried out in our laboratory have been aimed at elucidating the structure of Ure2 fibrils, the mechanism of amyloid formation and the effect of chaperones on the fibril formation of Ure2.
Conference Article| September 21 2011
The yeast prion protein Ure2: insights into the mechanism of amyloid formation
Elizabeth B. Sawyer;
Sarah Perrett 2
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
2To whom correspondence should be addressed (email email@example.com).
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Li-Jun Chen, Elizabeth B. Sawyer, Sarah Perrett; The yeast prion protein Ure2: insights into the mechanism of amyloid formation. Biochem Soc Trans 1 October 2011; 39 (5): 1359–1364. doi: https://doi.org/10.1042/BST0391359
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