Despite the availability of various classes of antimycotics, the treatment of patients with systemic fungal infections is challenging. Therefore the development of new antifungals is urgently required. Promising new antifungal candidates are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail.
Conference Article| September 21 2011
Apoptosis-inducing antifungal peptides and proteins
Katrijn De Brucker;
Bruno P.A. Cammue;
Karin Thevissen 1
1CMPG (Centre of Microbial and Plant Genetics), Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Katrijn De Brucker, Bruno P.A. Cammue, Karin Thevissen; Apoptosis-inducing antifungal peptides and proteins. Biochem Soc Trans 1 October 2011; 39 (5): 1527–1532. doi: https://doi.org/10.1042/BST0391527
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