FOH (farnesol), a non-sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been shown to inhibit proliferation and induce apoptosis. We have been using Aspergillus nidulans and FOH as a model system and cell death stimulus, respectively, aiming to understand by which means filamentous fungi are driven towards cell death. Here, we review some of our findings about FOH-induced cell death in A. nidulans.
Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans
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Taísa Magnani Dinamarco, Maria Helena S. Goldman, Gustavo Henrique Goldman; Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. Biochem Soc Trans 1 October 2011; 39 (5): 1544–1548. doi: https://doi.org/10.1042/BST0391544
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