NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent Ca2+-mobilizing messenger implicated in many Ca2+-dependent cellular processes. It is highly unusual in that it appears to trigger Ca2+ release from acidic organelles such as lysosomes. These signals are often amplified by archetypal Ca2+ channels located in the endoplasmic reticulum. Recent studies have converged on the TPCs (two-pore channels) which localize to the endolysosomal system as the likely primary targets through which NAADP mediates its effects. ‘Chatter’ between TPCs and endoplasmic reticulum Ca2+ channels is disrupted when TPCs are directed away from the endolysosomal system. This suggests that intracellular Ca2+ release channels may be closely apposed, possibly at specific membrane contact sites between acidic organelles and the endoplasmic reticulum.
Conference Article| January 19 2012
Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
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Sandip Patel, Eugen Brailoiu; Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?. Biochem Soc Trans 1 February 2012; 40 (1): 153–157. doi: https://doi.org/10.1042/BST20110693
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