Mitochondria may function as multiple separate organelles or as a single electrically coupled continuum to modulate changes in [Ca2+]c (cytoplasmic Ca2+ concentration) in various cell types. Mitochondria may also be tethered to the internal Ca2+ store or plasma membrane in particular parts of cells to facilitate the organelles modulation of local and global [Ca2+]c increases. Differences in the organization and positioning contributes significantly to the at times apparently contradictory reports on the way mitochondria modulate [Ca2+]c signals. In the present paper, we review the organization of mitochondria and the organelles role in Ca2+ signalling.
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Conference Article| January 19 2012
Mitochondrial organization and Ca2+ uptake
Marnie L. Olson;
John G. McCarron
John G. McCarron 1
1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0NR, U.K.
1To whom correspondence should be addressed (email email@example.com).
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Marnie L. Olson, Susan Chalmers, John G. McCarron; Mitochondrial organization and Ca2+ uptake. Biochem Soc Trans 1 February 2012; 40 (1): 158–167. doi: https://doi.org/10.1042/BST20110705
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