The IP3R (inositol 1,4,5-trisphosphate receptor) releases Ca2+ from the ER (endoplasmic reticulum) store upon binding to its ligand InsP3, which is thought to be generated by activation of certain membrane-bound G-protein-coupled receptors in Drosophila. Depletion of Ca2+ in the ER store also activates SOCE (store-operated Ca2+ entry) from the extracellular milieu across the plasma membrane, leading to a second rise in cytosolic Ca2+, which is then pumped back into the ER. The role of the IP3R and SOCE in mediating Ca2+ homoeostasis in neurons, their requirement in neuronal function and effect on neuronal physiology and as a consequence behaviour, are reviewed in the present article.
Conference Article| January 19 2012
IP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila
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Sumita Chakraborty, Gaiti Hasan; IP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila. Biochem Soc Trans 1 February 2012; 40 (1): 279–281. doi: https://doi.org/10.1042/BST20110618
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